If participants had been supplied two different concurrent

We determined this dose by calculating the total number of milligrams dispensed from all prescriptions filled in the previous 15 months intended for drug use in the year before the index date. If participants had been supplied two different concurrent prescriptions for levothyroxine, we used the more recent dose for the overlapping days. We determined the distribution of the cumulative daily dose to be a minimum of 0.018 mg to a maximum of 158.5 mg (median 24.94 mg).

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